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KMID : 0356919930260030493
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Korean Journal of Anesthesiology
1993 Volume.26 No. 3 p.493 ~ p.498
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Effects of the Dose of Protamine Sulfate Calculated by the Dose Response Curve Method or the Fixed Dose Method on the Activated Coagulation Time
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Abstract
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We studied 37 patients in order to evaluate the heparin-neutralizing efficacy of the protamine dose calculated by either the fixed dose method or the dose response curve method on the activated coagulation time(ACT) during open heart surgery.
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to the method calculating the protamine dose, the patients were randomly allocated to receive the protamine dose calculated t either the fixed dose method(N=17) or the dose response curve method(N=20). The ACT was measured at immediately after
sternotomy(baseline ACT) and 5 minutes after protamine administration(post-protamine ACT). There were no significant differences in baseline ACT or post-protamine ACT values between the two groups. The baseline ACT values in each group were not
significantly different from those of post-protamine ACT. The patient numbers of post-protamine ACT values over 130 seconds and the difference from baseline ACT to post-protamine ACT were not significantly different between both groups.
The results suggest the a dose of protamine sulfate calculated by a fixed dose method instead of a dose response curve method is available for neutralizing a heparin effect during open heart surgery.
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